Determining the Cause

Chief Complaint: Headache

a. History: Episodic

b. Physical Exam: Palpitation and diaphoresis, along with severe hypertension

Lab Test: Hyperglycemia

d. VMA: Positive

Differential Diagnosis

Pheochromocytoma

Pivotal Assessment Findings
CT Scan* Adrenal Mass    

*

CT scans can detect adrenal masses with a spatial resolution of 1 cm or greater with 85–95% accuracy. However, CT scan findings may not be specific enough to distinguish pheochromocytoma masses from other adrenal masses. 
On a non-contrast CT scan, pheochromocytomas can appear solid, complex, cystic, or have soft-tissue attenuation or low density. Most pheochromocytomas have an attenuation value greater than 10 HU, but some fat-containing pheochromocytomas may have values similar to adenomas. Pheochromocytomas can also appear high density due to hemorrhage. After contrast administration, pheochromocytomas tend to enhance very brightly, and some may enhance more on the arterial phase, while others enhance more on the portal venous phase. However, pheochromocytomas often cannot be reliably differentiated from adenomas using CT washout protocols. 
Other imaging studies that can be used to detect pheochromocytomas include: 
  • MRI: More specific than CT scanning, but some patients cannot tolerate it. MRI is preferred for children and pregnant or lactating women. 
  • Scintigraphy: Reserved for cases where CT scanning or MRI doesn't show a tumor. 
  • PET scanning: A promising technique for detection and localization. 18F-DOPA PET is considered highly sensitive, and Gallium-68 DOTATATE PET-CT imaging has high specificity for pheochromocytoma. 
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    • A review of the patient’s family history helps identify hereditary syndromes.
  1. Laboratory Tests:

    • Blood Tests: Measure hormone levels, including catecholamines and metanephrines.
    • Urine Tests: Check for hormone levels.
  2. Imaging Studies:

    • CT Scan: Used to visualize the tumor.
    • Magnetic Resonance Imaging (MRI): Helps detect tumors or other conditions.
    • M-iodobenzylguanidine (MIBG) Imaging: Detects radioactive substances taken up by the tumor.
    • Positron Emission Tomography (PET): Also detects radioactive substances in the tumor.
  3. Genetic Testing:

    • Determines if the tumor is part of an inherited syndrome by looking for specific genetic mutations.
  4. Treatment Options:

    • Surgical removal of the tumor is the primary choice.
    • Medication may be needed to manage symptoms.
    • Chemotherapy or radiation therapy may be used for malignant pheochromocytomas.
  5. Specialists Involved:

    • Endocrinologist: Specializes in endocrine system disorders.
    • Surgeon: Performs medical operations.

Remember, if you or someone you know shows symptoms of pheochromocytoma (such as high blood pressure, palpitations, sweating, or headache), seek medical attention promptly1.{% if Copilot_language == “Español” %} ¡Espero que esta información te sea útil!{% elif Copilot_language == “Français” %} J’espère que ces informations vous seront utiles !{% elif Copilot_language == “Deutsch” %} Ich hoffe, diese Informationen sind hilfreich!{% endif %}

 

 

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